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Rethinking the relationships between chronic rhinosinusitis and asthma severity
Sapideh Gilani1, Neil Bhattacharyya2
1Department of Otolaryngology, University of California, San Diego Medical Center, 200 West Arbor Drive MC 8654, San Diego, CA 92103, United States of America.
American Journal of Otolaryngology
|March 10, 2023
Summary
Chronic rhinosinusitis (CRS) is linked to more severe asthma classifications. However, CRS comorbidity did not increase oral corticosteroid use or affect oxygen saturation in asthma patients.
Area of Science:
- Pulmonology
- Otolaryngology
- Epidemiology
Background:
- Previous research called for studies on chronic rhinosinusitis (CRS) treatment effects on asthma outcomes.
- The unified airway theory suggests shared pathophysiology between asthma and CRS, but supporting data is limited.
Purpose of the Study:
- To investigate the association between chronic rhinosinusitis (CRS) and asthma severity.
- To determine if CRS comorbidity impacts asthma management, specifically oral corticosteroid (OCS) use and oxygen saturation.
Main Methods:
- A case-control study matched 1321 asthma patients with CRS against 1321 asthma patients without CRS.
- Asthma severity, oral corticosteroid (OCS) use, and oxygen saturation were compared between groups.
Main Results:
- Asthma patients with CRS had a significantly higher classification of severe asthma (38.9%) compared to controls (25.7%).
- No statistically significant differences were observed in oral corticosteroid (OCS) prescription rates or mean/minimum oxygen saturation between the groups.
Conclusions:
- Increased asthma severity classification is associated with a diagnosis of chronic rhinosinusitis (CRS).
- CRS comorbidity in asthma patients is not linked to increased OCS use or altered oxygen saturation.
- The study findings do not support the unified airway theory's proposed causative link between upper and lower airway conditions.
Keywords:
AdultAirwayAsthmaChronic rhinosinusitisClinicInflammationLungsMedicationOtolaryngologyOxygenPharmacologyPulmonarySaturationSinusSteroidsTreatmentUnified Airway TheoryMore Related Videos
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