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Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Aug 7, 2025

Merkel Cell Polyomavirus Infection and Detection
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Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

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Merkel cell carcinoma: an update.

Ryan C DeCoste1, Michael D Carter1, Thai Yen Ly1

  • 1Department of Pathology and Laboratory Medicine, QEII Health Science Centre, Nova Scotia Health, Halifax, Nova Scotia, B3H 1V8, Canada; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, B3H 1V8, Canada.

Human Pathology
|March 10, 2023
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma (MCC), a rare skin cancer, has two main causes: viral infection or UV radiation. New immunotherapies offer hope for treating this aggressive disease.

Keywords:
Cutaneous malignancyImmunotherapyMerkel cell carcinomaNeuroendocrine carcinomaUV radiation

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Area of Science:

  • Oncology
  • Dermatopathology
  • Virology

Background:

  • Merkel cell carcinoma (MCC) is an uncommon neuroendocrine skin cancer with a poor prognosis.
  • Recent advancements have significantly improved our understanding of MCC biology.
  • MCC is now recognized as an ontogenetically dichotomous group of neoplasms.

Purpose of the Study:

  • To review fundamental and emerging concepts in Merkel cell carcinoma.
  • To highlight topics of practical relevance for surgical and dermatopathologists.
  • To discuss the implications of MCC's dichotomous origins and new therapeutic options.

Main Methods:

  • Review of recent scientific literature on Merkel cell carcinoma.
  • Analysis of the etiological factors (viral vs. UV-associated).
  • Discussion of immunohistochemical and molecular characterization.

Main Results:

  • MCC arises from two distinct oncogenic pathways: Merkel cell polyomavirus or UV radiation.
  • These distinct origins impact molecular and immunohistochemical profiles.
  • Immunotherapeutics represent a significant advancement in MCC management.

Conclusions:

  • Understanding the dichotomous origins of MCC is crucial for diagnosis and prognosis.
  • Emerging immunotherapies offer promising treatment avenues for aggressive MCC.
  • This review provides practical insights for clinicians managing Merkel cell carcinoma.