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Hepatic uptake of gluconeogenic substrates in late-pregnant and mid-lactating rats
J Casado1, X Remesar, M Pastor-Anglada
1Department de Bioquímica i Fisiologia, Universitat de Barcelona, Facultal de Biologia, Spain.
Bioscience Reports
|July 1, 1987
Abstract:
Lactate uptake by liver is markedly increased in late-pregnant and mid-lactating rats without concomitant changes in its availability. Glycerol contribution to the liver 3-C unit uptake is only significant at term gestation (50% of lactate uptake) but almost negligible at mid-lactation (10% of lactate uptake). Pyruvate is only taken up by the liver of 15-day lactating rats. As a general trend, the livers of either pregnant or lactating rats are provided with an enhanced capacity to take up gluconeogenic substrates.