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Mitochondrial pyruvate carrier--a possible link between gluconeogenesis and ketogenesis in the liver
1Laboratory for Endocrinology & Metabolism, Charles University, Faculty of Medicine, Prague, Czechoslovakia.
Bioscience Reports
|July 1, 1987
Abstract:
Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.