Detection and Imaging of Active Substances in Early Atherosclerotic Lesions Using Fluorescent Probes
Jin Li1, Jiheng Xu2, Wei Zhang1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for, Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Biomedical Sciences, Shandong Normal University, Jinan, 250014, P. R. China.
Insights
Optical imaging probes offer new ways to detect atherosclerosis (AS) early. This review covers recent advancements in optical probes for AS imaging, highlighting challenges and future directions for better cardiovascular disease management.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Cardiovascular Research
Background:
- Atherosclerosis (AS) is a chronic inflammatory vascular disease linked to lipids, causing major cardiovascular events like heart attack and stroke.
- Early-stage AS is often asymptomatic, lacking significant vascular stenosis, which hinders timely intervention and treatment.
- Effective early detection and imaging are crucial for managing AS and preventing severe complications.
Purpose of the Study:
- To provide a comprehensive review of recent optical probes for atherosclerosis detection and imaging.
- To discuss the role of novel biomarkers in targeted AS imaging.
- To outline current challenges and future prospects in the field of optical imaging for atherosclerosis.
Main Methods:
- Review of recent scientific literature on optical probes and imaging techniques for atherosclerosis.
- Analysis of identified biomarkers suitable for targeted atherosclerosis imaging.
- Synthesis of information on technological advancements and challenges in the field.
Main Results:
- Significant progress has been made in developing diverse optical imaging methods and targeted probes for atherosclerosis.
- Numerous biomarkers are being identified as potential targets for enhanced AS detection.
- The review consolidates current knowledge on optical probe applications in atherosclerosis imaging.
Conclusions:
- Optical imaging probes represent a promising avenue for the early assessment and treatment of atherosclerosis.
- Continued research into novel probes and biomarkers is essential for improving diagnostic capabilities.
- Addressing current challenges will pave the way for more effective clinical applications in cardiovascular disease management.
Abstract:
Atherosclerosis (AS) is a vascular disease caused by chronic inflammation and lipids that is the main cause of myocardial infarction, stroke and other cardiovascular diseases. Atherosclerosis is often difficult to detect in its early stages due to the absence of clinically significant vascular stenosis. This is not conducive to early intervention or treatment of the disease. Over the past decade, researchers have developed various imaging methods for the detection and imaging of atherosclerosis. At the same time, more and more biomarkers are being found that can be used as targets for detecting atherosclerosis. Therefore, the development of a variety of imaging methods and a variety of targeted imaging probes is an important project to achieve early assessment and treatment of atherosclerosis. This paper provides a comprehensive review of the optical probes used to detect and target atherosclerosis imaging in recent years, and describes the current challenges and future development directions.
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