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ISL1 controls pancreatic alpha cell fate and beta cell maturation

Romana Bohuslavova1, Valeria Fabriciova2, Laura Lebrón-Mora2

  • 1Laboratory of Molecular Pathogenetics, Institute of Biotechnology CAS, 25250, Vestec, Czechia. romana.bohuslavova@ibt.cas.cz.

Cell & Bioscience
|March 10, 2023
PubMed
Summary

The transcription factor ISL1 is crucial for generating functional pancreatic alpha and beta cells. Its elimination disrupts cell development and leads to a diabetic phenotype, highlighting its role in glucose homeostasis.

Keywords:
Epigenetic histone modificationPancreas developmentPancreatic endocrine cellsTranscriptome

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