[Protein synthesis and content of free amino acids in rat organs in experimental peritonitis]

Experiments performed on rats shown that in peritonitis the mass of the animal's organs and C14-amino acid incorporation into tissue proteins is reduced. Free amino acid content in tissues and serum is increased. Decreased incorporation of C14-amino acid into hepatic proteins antecedes the increase of free amino acid content in this organ. In the kidneys, spleen and skeletal muscles diminished synthesis of proteins and increased protein catabolism occur simultaneously. It was shown that during the initial 24 hours of peritonitis the amino acid exchange between organs and systemic circulation are disturbed, however, the diminished synthesis of tissue proteins is not the result of free amino acid deficiency.