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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Bile01:19

Bile

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Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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Related Experiment Video

Updated: Aug 7, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Bile Acids and Biliary Fibrosis.

Sayed Obaidullah Aseem1,2, Phillip B Hylemon3,4, Huiping Zhou3,4

  • 1Stravitz-Sanyal Institute for Liver Disease & Metabolic Health, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Cells
|March 11, 2023
PubMed
Summary

Bile acids are key drivers of biliary fibrosis in cholangiopathies like primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Understanding bile acid signaling offers new therapeutic targets for these liver diseases.

Keywords:
bile acid receptorsbile acidsbiliary fibrosischolangiocytescholangiopathies

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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Area of Science:

  • Hepatology and Gastroenterology
  • Molecular and Cellular Biology

Background:

  • Biliary fibrosis is central to cholangiopathies, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
  • These conditions involve cholestasis (impaired bile flow) and dysregulated bile acid homeostasis, which can exacerbate fibrosis.

Purpose of the Study:

  • To review the critical role of bile acids in the pathogenesis and progression of biliary fibrosis.
  • To explore the impact of bile acid signaling pathways and receptors on cholangiocyte function and fibrosis.
  • To examine the link between bile acid signaling and epigenetic mechanisms in biliary fibrosis.

Main Methods:

  • Literature review of animal models and human studies on bile acids in cholangiopathies.
  • Analysis of research on bile acid receptors and their downstream signaling pathways.
  • Synthesis of findings on epigenetic modifications related to bile acid signaling.

Main Results:

  • Bile acids are increasingly recognized as crucial mediators in the development and worsening of biliary fibrosis.
  • Bile acid receptors modulate cholangiocyte functions, influencing fibrotic processes.
  • Emerging evidence connects bile acid signaling to epigenetic regulation in biliary fibrosis.

Conclusions:

  • Bile acid dysregulation significantly contributes to biliary fibrosis in PBC and PSC.
  • Targeting bile acid signaling pathways and receptors presents promising therapeutic strategies for cholangiopathies.
  • Further research into bile acid-epigenetic interactions may reveal novel treatment avenues.