Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

577
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
577
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.1K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.1K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

21
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The American College of Rheumatology Updated Recommended Methods for Development of Disease Classification and Response Criteria.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Segmental spinal damage predicts mobility restriction and functional decline in radiographic axial spondyloarthritis: a longitudinal study.

Rheumatology (Oxford, England)·2026
Same author

Refractory Systemic Sclerosis-Related Digital Ulcer Successfully Treated With Hyperbaric Oxygen Therapy: A Case Report and Literature Review.

The Journal of rheumatology·2025
Same author

Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody-Positive Individuals.

Arthritis & rheumatology (Hoboken, N.J.)·2025
Same author

Improving Systemic Sclerosis Quality of Care.

The Journal of rheumatology·2025
Same author

Reply.

Arthritis & rheumatology (Hoboken, N.J.)·2025

Related Experiment Video

Updated: Aug 7, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

135.0K

Advanced Autoantibody Testing in Systemic Sclerosis.

Kholoud Almaabdi1, Zareen Ahmad1, Sindhu R Johnson1,2,3

  • 1Toronto Scleroderma Program, Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON M5T 1R8, Canada.

Diagnostics (Basel, Switzerland)
|March 11, 2023
PubMed
Summary

Advanced autoantibody testing aids in diagnosing and predicting outcomes for systemic sclerosis patients. Expanded testing profiles offer greater clinical insight beyond traditional markers like antinuclear antibody (ANA).

Keywords:
antibodiessclerodermasystemic sclerosis

More Related Videos

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

12.9K
Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

36.1K

Related Experiment Videos

Last Updated: Aug 7, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

135.0K
Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

12.9K
Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

36.1K

Area of Science:

  • Rheumatology
  • Immunology
  • Autoimmune Diseases

Background:

  • Systemic sclerosis is a complex autoimmune disease involving immune dysfunction, vascular damage, and fibrosis.
  • Autoantibody testing is crucial for diagnosis and prognosis in systemic sclerosis.
  • Traditional autoantibody tests include antinuclear antibody (ANA), anti-Scl-70, and anticentromere antibodies.

Purpose of the Study:

  • To review the epidemiology, clinical associations, and prognostic significance of advanced autoantibody testing in systemic sclerosis.
  • To highlight the benefits of expanded autoantibody profiles for clinicians.
  • To provide an updated overview of diagnostic and prognostic markers.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of epidemiological data.
  • Correlation of autoantibody profiles with clinical manifestations and outcomes.

Main Results:

  • Expanded autoantibody testing provides a more comprehensive understanding of systemic sclerosis subtypes.
  • Specific autoantibodies are associated with distinct clinical features and prognoses.
  • Access to advanced testing has improved clinical decision-making.

Conclusions:

  • Advanced autoantibody testing is essential for accurate diagnosis and prognostication in systemic sclerosis.
  • The expanded autoantibody profile offers significant clinical utility beyond traditional markers.
  • Further research into novel autoantibodies may refine disease management.