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Updated: Aug 7, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Published on: September 20, 2016

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors

Praewa Suthapot1,2,3, Wararat Chiangjong4, Parunya Chaiyawat3,5

  • 1Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Cancers
|March 11, 2023
PubMed

Insights

Precision medicine in pediatric cancers shows promise, identifying genetic targets for targeted therapies. This review highlights genetic markers for childhood solid tumors and future treatment strategies.

Area of Science:

  • Oncology
  • Genetics
  • Pediatrics

Background:

  • Biomarker-driven trials have improved outcomes in adult cancers.
  • Pediatric cancers have unique mutation profiles and fewer recurrent alterations, slowing progress.
  • Recent advances identify genomic and transcriptomic profiles in childhood malignancies.

Purpose of the Study:

  • To review known and potential genetic markers for pediatric solid tumors.
  • To discuss precise therapeutic strategies for childhood cancers.

Main Methods:

  • Literature review of genetic testing and precision medicine in pediatric oncology.
  • Analysis of genomic alterations and transcriptomic profiles in pediatric neoplasms.

Main Results:

  • Biomarker-driven trials show success in adult cancers but lag in pediatric cancers.
  • Identification of specific genomic alterations and transcriptomic profiles in pediatric patients.
  • Potential for novel therapeutic targets in rare and difficult-to-access pediatric neoplasms.

Conclusions:

  • Precision medicine offers significant opportunities for treating pediatric solid tumors.
  • Further investigation into genetic markers and targeted therapies is crucial for advancing pediatric cancer care.
Keywords:
actionable mutationspediatric solid tumorprecision medicine

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