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Area of Science:

  • Medical Imaging
  • Oncology
  • Artificial Intelligence

Background:

  • Prostate cancer is a leading global cancer, necessitating advanced clinical aid systems for early detection and treatment.
  • Current segmentation models for prostate gland and zones require comparative evaluation for improved clinical utility.

Purpose of the Study:

  • To comparatively analyze common segmentation models for prostate gland and zones.
  • To evaluate the efficacy of object detection as a pre-processing step for prostate segmentation.

Main Methods:

  • Retrospective study utilizing two public datasets for cross-validation and external testing.
  • Comparative evaluation of deep learning segmentation models.
  • Assessment of object detection pre-processing impact on segmentation performance.

Main Results:

  • Most segmentation models performed similarly, with nnU-Net demonstrating consistent outperformance.
  • Models trained on object-detector-cropped data showed improved generalization.
  • Object detection pre-processing led to better external test set performance despite lower cross-validation scores.

Conclusions:

  • Model selection has minimal impact on segmentation accuracy, except for nnU-Net's superior performance.
  • Object detection pre-processing enhances the generalization capabilities of prostate segmentation models.
  • Further research into object detection integration can optimize clinical aid systems for prostate cancer.