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Updated: Aug 7, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Development and Experimental Validation of a Novel Prognostic Signature for Gastric Cancer
Chengcheng Liu1,2,3, Yuying Huo1, Yansong Zhang4
1School of Software Engineering, Beijing Jiaotong University, Beijing 100044, China.
Background:
Gastric cancer is a malignant tumor with high morbidity and mortality. Therefore, the accurate recognition of prognostic molecular markers is the key to improving treatment efficacy and prognosis.
Methods:
In this study, we developed a stable and robust signature through a series of processes using machine-learning approaches. This PRGS was further experimentally validated in clinical samples and a gastric cancer cell line.
Results:
The PRGS is an independent risk factor for overall survival that performs reliably and has a robust utility. Notably, PRGS proteins promote cancer cell proliferation by regulating the cell cycle. Besides, the high-risk group displayed a lower tumor purity, higher immune cell infiltration, and lower oncogenic mutation than the low-PRGS group.
Conclusions:
This PRGS could be a powerful and robust tool to improve clinical outcomes for individual gastric cancer patients.
