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Related Experiment Videos

Mouse paw edema. A new model for inflammation?

M G Henriques1, P M Silva, M A Martins

  • 1Departamento de Fisiologia e Farmacodinâmica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|January 1, 1987
PubMed
Summary

Carrageenan injection in mice causes biphasic paw edema, with a dose-dependent response emerging after 24 hours. This model is valuable for studying inflammation and screening new anti-inflammatory drugs.

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Area of Science:

  • Pharmacology
  • Immunology
  • Toxicology

Background:

  • Carrageenan is a widely used agent to induce experimental inflammation.
  • Understanding the temporal and cellular dynamics of carrageenan-induced edema is crucial for developing effective anti-inflammatory therapies.

Purpose of the Study:

  • To characterize the biphasic nature of carrageenan-induced paw edema in mice.
  • To investigate the cellular infiltrate and hematological changes associated with this inflammatory model.
  • To evaluate the efficacy of established anti-inflammatory drugs in mitigating carrageenan-induced edema.

Main Methods:

  • Carrageenan was injected into the mouse paw to induce edema.
  • Edema intensity and dose-response relationships were measured over 72 hours.

Related Experiment Videos

  • Histological analysis examined cellular infiltration in the paw tissue.
  • The effects of indomethacin and dexamethasone pretreatment were assessed.

    • Main Results:

    • Carrageenan induced a biphasic edema response, with a dose-dependent increase in the second phase (after 24h).
    • Early phase (up to 24h) showed low-intensity edema, while the second phase peaked at 72h.
    • Histology revealed neutrophil infiltration at 4h, followed by macrophages, eosinophils, and lymphocytes at 48-72h.
    • Increased circulating leukocytes and platelets were observed during the later phase.
    • Indomethacin and dexamethasone dose-dependently reduced both phases of edema.

    Conclusions:

    • Carrageenan-induced mouse paw edema exhibits distinct early and late inflammatory phases.
    • The model demonstrates significant cellular infiltration and hematological alterations.
    • This model is effective for studying inflammatory mediators and screening novel anti-inflammatory drugs.