Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Segmental pancreatic transplantation in pigs.

G K Kyriakides, F Q Nuttall, J Miller

|February 1, 1979

Summary

Segmental pancreatic allotransplants in pigs prevented hyperglycemia for 33 days. Grafts without duct ligation showed better preservation, suggesting a viable model for pancreatic transplantation research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2006

Same author

HLA class I donor-specific triplet antibodies detected after renal transplantation.

Transplantation proceedings·2004

Same author

Effect of protein ingestion on the glucose appearance rate in people with type 2 diabetes.

The Journal of clinical endocrinology and metabolism·2001

Same author

Glucose appearance rate after the ingestion of galactose.

Metabolism: clinical and experimental·2001

Same author

Uric acid inhibits liver phosphorylase a activity under simulated in vivo conditions.

American journal of physiology. Endocrinology and metabolism·2001

Same author

Peripheral glucose appearance rate following fructose ingestion in normal subjects.

Metabolism: clinical and experimental·2001

Area of Science:

Transplantation immunology
Surgical innovation
Endocrinology

Background:

Pancreatic transplantation is a potential treatment for diabetes.
Developing effective surgical techniques and immunosuppressive strategies is crucial.
Intraperitoneal allotransplantation offers an alternative approach.

Observation:

Segmental pancreatic allotransplants were performed intraperitoneally in pigs.
Exocrine function was suppressed using glucagon.
Immunosuppression included methylprednisolone and cyclophosphamide, with some receiving antilymphocyte globulin (ALG).

Findings:

Allotransplantation successfully prevented hyperglycemia in pancreatectomized pigs for up to 33 days.
Grafts without duct ligation demonstrated superior tissue preservation, avoiding obstructive damage.
No intraperitoneal inflammatory or infectious complications were observed, attributed to glucagon suppression and peritoneal absorption.

Implications:

This study presents a promising physiological model for pancreatic transplantation research.
The findings suggest that duct management and exocrine function suppression are key factors in graft survival.
Further optimization of antirejection therapies is necessary for clinical translation.

Related Experiment Videos