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Pathways of Coagulopathy and Inflammatory Response in SARS-CoV-2 Infection among Type 2 Diabetic Patients

Orsolya-Zsuzsa Akácsos-Szász1, Sándor Pál2, Kinga-Ilona Nyulas1

  • 1Doctoral School, Faculty of Medicine, George Emil Palade University of Medicine Pharmacy, Science, and Technology of Târgu Mureş, 540142 Târgu-Mureș, Romania.

International Journal of Molecular Sciences
|March 11, 2023
PubMed

Insights

Diabetic patients with COVID-19 face high mortality due to blood clots. This review details the complex mechanisms linking diabetes, inflammation, and COVID-19-related coagulopathy for better patient management.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Endocrinology

Background:

  • Diabetic patients exhibit chronic inflammation and endothelial dysfunction.
  • COVID-19 infection exacerbates these conditions, leading to increased mortality, particularly from thromboembolic events.
  • Diabetes mellitus is a significant risk factor for severe COVID-19 outcomes.

Purpose of the Study:

  • To elucidate the underlying pathomechanisms of COVID-19-related coagulopathy in diabetic patients.
  • To synthesize current scientific understanding of the interplay between diabetes and SARS-CoV-2 infection concerning vascular and clotting disorders.
  • To identify key factors contributing to arteriopathy and thrombosis in this vulnerable population.

Main Methods:

  • Systematic literature review and data synthesis.
  • Comprehensive search of scientific databases including Cochrane, PubMed, and Embase.
  • Analysis of recent research on COVID-19, diabetes, and coagulopathy.

Main Results:

  • Detailed presentation of complex interrelations between various factors and pathways involved in arteriopathy and thrombosis.
  • Identification of genetic and metabolic factors influencing COVID-19 course in diabetic individuals.
  • Elucidation of SARS-CoV-2-related vasculopathy and coagulopathy mechanisms in diabetes.

Conclusions:

  • Understanding these pathomechanisms is crucial for managing COVID-19 in diabetic patients.
  • Enhanced knowledge facilitates improved diagnostic and therapeutic strategies for this high-risk group.
  • This review provides a foundation for more effective clinical management of COVID-19-associated coagulopathy in diabetes.

Keywords:
COVID-19coagulopathydiabetes mellitusinflammationthrombosisvasculopathy

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