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Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

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Published on: December 15, 2023

Neuroprotective Strategies for Ischemic Stroke-Future Perspectives.

Matteo Haupt¹, Stefan T Gerner^2,3, Mathias Bähr¹

¹Department of Neurology, University of Göttingen Medical School, 37075 Göttingen, Germany.

International Journal of Molecular Sciences

|March 11, 2023

Summary

New neuroprotective strategies are crucial for stroke treatment, as current therapies have limited eligibility. This review explores traditional drugs, stem cells, extracellular vesicles, and the microbiota-gut-brain axis for neuroprotection.

Keywords:

cerebral ischemia extracellular vesicle microbiota–gut–brain axis neuroprotection stem cells stroke

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Published on: February 2, 2017

Area of Science:

Neuroscience
Cerebrovascular Medicine
Regenerative Medicine

Background:

Ischemic stroke is a leading cause of death and disability globally.
Current acute treatments like thrombolysis and thrombectomy have limited patient eligibility.
There is an urgent need for novel neuroprotective therapies to improve stroke outcomes.

Purpose of the Study:

To provide an overview of current research in neuroprotective stroke treatment.
To discuss traditional neuroprotective agents, stem cell-based therapies, and extracellular vesicles.
To explore the potential of the microbiota-gut-brain axis as a future therapeutic target.

Main Methods:

Literature review of preclinical and clinical studies on neuroprotection in ischemic stroke.
Analysis of traditional neuroprotective approaches targeting inflammation, cell death, and excitotoxicity.
Evaluation of emerging strategies including stem cell therapy, extracellular vesicles, and microbiota modulation.

Main Results:

Numerous preclinical neuroprotective agents show promise but lack successful clinical translation.
Stem cell-based treatments and extracellular vesicles offer potential for neural repair and regeneration.
The microbiota-gut-brain axis presents a novel, yet underexplored, avenue for neuroprotection.

Conclusions:

Translating neuroprotective strategies from bench to bedside remains a significant challenge.
A multi-faceted approach combining traditional and novel therapies may be necessary for effective stroke management.
Targeting the microbiota-gut-brain axis holds promise for future neuroprotective interventions in stroke recovery.