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Related Concept Videos

The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Drug Binding to Blood Components01:30

Drug Binding to Blood Components

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When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Updated: Aug 7, 2025

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic

Carolin Pozder1, Elles M Screever1,2, A Rogier van der Velde1

  • 1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

International Journal of Molecular Sciences
|March 11, 2023
PubMed
Summary

Galectin-3 binds more strongly to red blood cells and von Willebrand factor in non-O blood groups, with lower plasma levels observed in these groups. This interaction may influence galectin-3

Keywords:
biomarkerblood groupgalectin-3prognosisvon Willebrand factor

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Area of Science:

  • Cardiovascular research
  • Biochemistry
  • Hematology

Background:

  • ABO blood group is associated with cardiovascular events.
  • Mechanisms linking blood groups to cardiovascular outcomes are unclear.
  • Galectin-3, a VWF ligand, may play a role.

Purpose of the Study:

  • Investigate galectin-3's role across different ABO blood groups.
  • Assess galectin-3 binding to red blood cells and VWF.
  • Determine galectin-3's prognostic value for mortality in relation to blood type.

Main Methods:

  • In vitro assays for galectin-3 binding to RBCs and VWF.
  • Plasma galectin-3 levels measured in LURIC and PREVEND cohorts.
  • Logistic and Cox regression models for mortality prediction.

Main Results:

  • Galectin-3 exhibited higher binding to RBCs and VWF in non-O blood groups.
  • Non-O blood groups showed significantly lower plasma galectin-3 levels.
  • Galectin-3 retained prognostic value for mortality across blood groups.

Conclusions:

  • Galectin-3 interaction with blood group epitopes influences its function.
  • Blood group may affect galectin-3's utility as a biomarker.
  • Further research is needed to understand galectin-3's biological activity and biomarker performance.