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Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance
Carolin Pozder1, Elles M Screever1,2, A Rogier van der Velde1
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
International Journal of Molecular Sciences
|March 11, 2023
Summary
Galectin-3 binds more strongly to red blood cells and von Willebrand factor in non-O blood groups, with lower plasma levels observed in these groups. This interaction may influence galectin-3
Area of Science:
- Cardiovascular research
- Biochemistry
- Hematology
Background:
- ABO blood group is associated with cardiovascular events.
- Mechanisms linking blood groups to cardiovascular outcomes are unclear.
- Galectin-3, a VWF ligand, may play a role.
Purpose of the Study:
- Investigate galectin-3's role across different ABO blood groups.
- Assess galectin-3 binding to red blood cells and VWF.
- Determine galectin-3's prognostic value for mortality in relation to blood type.
Main Methods:
- In vitro assays for galectin-3 binding to RBCs and VWF.
- Plasma galectin-3 levels measured in LURIC and PREVEND cohorts.
- Logistic and Cox regression models for mortality prediction.
Main Results:
- Galectin-3 exhibited higher binding to RBCs and VWF in non-O blood groups.
- Non-O blood groups showed significantly lower plasma galectin-3 levels.
- Galectin-3 retained prognostic value for mortality across blood groups.
Conclusions:
- Galectin-3 interaction with blood group epitopes influences its function.
- Blood group may affect galectin-3's utility as a biomarker.
- Further research is needed to understand galectin-3's biological activity and biomarker performance.
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