Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

53
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
53

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Composition of Different Herbal Extracts and Their Impact on Initial Bacterial Colonization on Enamel In Situ.

Plants (Basel, Switzerland)·2026
Same author

Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation.

International journal of molecular sciences·2026
Same author

Influencing viable oral bacteria in the patient's oral cavity and on the dentist's mask.

BMC oral health·2026
Same author

Circulating DNA and Neutrophil-Derived Biomarkers in Neonatal Sepsis.

International journal of molecular sciences·2026
Same author

The oral-vascular axis: immune mechanisms linking periodontal dysbiosis to systemic vascular pathology.

Frontiers in immunology·2026
Same author

Effects of <i>Fragaria vesca</i> leaf extract on the initial pellicle-an atypical representative among polyphenol-containing substances.

Frontiers in oral health·2026

Related Experiment Video

Updated: Aug 7, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

4.2K

Breaking the Gingival Barrier in Periodontitis.

Ljubomir Vitkov1,2,3, Jeeshan Singh4,5, Christine Schauer4,5

  • 1Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, 66421 Homburg, Germany.

International Journal of Molecular Sciences
|March 11, 2023
PubMed
Summary

Mechanical forces like chewing can cause bacteria to enter the bloodstream from inflamed gums, leading to low-grade inflammation. This occurs when gum tissue damage weakens the epithelial barrier, allowing bacterial translocation.

Keywords:
Oncostatin Mbarrier breakepithelial discontinuitymechanical damagesneutrophilsstretchingtight junctionstissue fracture

More Related Videos

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.1K
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

10.9K

Related Experiment Videos

Last Updated: Aug 7, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

4.2K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.1K
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

10.9K

Area of Science:

  • Oral biology
  • Periodontology
  • Immunology

Background:

  • The epithelial barrier of the gingiva plays a crucial role in periodontal pathology and systemic inflammation.
  • Mechanically induced bacterial translocation in the gingiva is often overlooked despite its implications.

Purpose of the Study:

  • To review the factors contributing to the breakdown of the gingival epithelial barrier.
  • To explore the translocation of bacteria and lipopolysaccharide (LPS) during mechanical forces.

Main Methods:

  • Literature review focusing on bacterial, immune, and mechanical factors affecting gingival barrier integrity.
  • Analysis of the impact of physiological mechanical forces on epithelial tight junctions (TJs).

Main Results:

  • Inflamed gingival TJs deteriorate due to factors like lipopolysaccharide (LPS), bacterial proteases, and Oncostatin M (OSM).
  • Deteriorated TJs rupture under mechanical forces (mastication, teeth brushing), causing transient bacteremia.
  • This process involves dynamic short-duration events with rapid repair mechanisms.

Conclusions:

  • Bacterial, immune, and mechanical factors collectively increase gingival barrier permeability.
  • Mechanical forces during mastication and brushing facilitate bacterial and LPS translocation in inflamed gingiva.
  • Understanding these mechanisms is vital for addressing periodontal pathology and systemic inflammation.