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Vitamin D as a Shield against Aging.

Cristina Fantini1, Clarissa Corinaldesi2, Andrea Lenzi3

  • 1Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.

International Journal of Molecular Sciences
|March 11, 2023
PubMed
Summary
This summary is machine-generated.

Vitamin D plays a crucial role in protecting against aging by influencing cellular processes and immune responses. Maintaining adequate vitamin D levels is vital for combating age-related decline and diseases.

Keywords:
cardiomyocytesimmunocytesimmunosenescenceinflammagingmolecular mechanismsskeletal muscle cellsvitamin D

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Area of Science:

  • Gerontology and Nutritional Immunology
  • Cellular Biology and Aging Mechanisms

Background:

  • Aging is characterized by cellular damage, loss of homeostasis, and immune system decline (immunosenescence).
  • Chronic inflammation (inflammaging) and oxidative stress increase with age, raising the risk of comorbidities.
  • Nutrition and micronutrients, like vitamin D, can modulate aging processes.

Purpose of the Study:

  • To review the role of vitamin D in geroprotection, focusing on its impact on cellular functions and immune responses.
  • To identify key molecular pathways of immunosenescence and inflammaging targeted by vitamin D.
  • To discuss the influence of vitamin D on heart and skeletal muscle health in aging.

Main Methods:

  • Literature review of studies on vitamin D, aging, immunosenescence, and inflammaging.
  • Analysis of biomolecular pathways affected by vitamin D status.
  • Examination of vitamin D's role in age-related cardiovascular and musculoskeletal conditions.

Main Results:

  • Vitamin D influences cellular/intracellular processes and modulates immune responses for protection against infections and age-related diseases.
  • Vitamin D targets key pathways involved in immunosenescence and inflammaging.
  • Vitamin D status affects heart and skeletal muscle cell function, with implications for hypovitaminosis D management.

Conclusions:

  • Vitamin D is a significant factor in geroprotection, impacting cellular health and immune function during aging.
  • Correction of vitamin D deficiency through diet and supplementation is important for mitigating age-related health issues.
  • Further research is needed to translate findings on vitamin D and aging into clinical practice, especially for the elderly population.