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Related Experiment Video

Updated: Jun 27, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Tannic Acid Tailored-Made Microsystems for Wound Infection.

Inês Guimarães1, Raquel Costa1, Sara Madureira1

  • 1Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

International Journal of Molecular Sciences
|March 11, 2023
PubMed
Summary

Chitosan-based microparticles loaded with tannic acid offer a novel solution for difficult-to-treat wound infections. These microparticles show potent antimicrobial activity and enhance wound healing by improving fibroblast viability and proliferation.

Keywords:
antimicrobialchitosan microparticlestannic acidwound infection

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Sciences
  • Infectious Diseases

Background:

  • Complex wounds with difficult-to-treat infections pose significant clinical and socio-economic challenges.
  • Increasing antibiotic resistance necessitates novel therapeutic strategies beyond conventional wound care.
  • Phytochemicals, like tannic acid, present promising antimicrobial and antioxidant properties for wound healing.

Purpose of the Study:

  • To design and develop chitosan (CS)-based microparticles (CM) as carriers for tannic acid (TA) to enhance its stability, bioavailability, and in situ delivery.
  • To evaluate the antimicrobial efficacy and biocompatibility of the developed tannic acid-loaded chitosan microparticles (CMTA) for wound care applications.

Main Methods:

  • Chitosan-based microparticles loaded with tannic acid (CMTA) were prepared using a spray-drying technique.
  • Characterization included encapsulation efficiency, kinetic release studies, particle morphology, and size analysis.
  • Antimicrobial activity was assessed against common wound pathogens (MRSA, MSSA, S. epidermidis, E. coli, C. albicans, P. aeruginosa) using agar diffusion assays.
  • Biocompatibility was evaluated using human dermal fibroblasts to assess cell viability and proliferation.

Main Results:

  • CMTA exhibited a satisfactory product yield of approximately 32% and a high encapsulation efficiency of approximately 99%.
  • The microparticles had diameters below 10 μm and a spherical morphology.
  • CMTA demonstrated significant antimicrobial activity against Gram-positive, Gram-negative, and yeast strains.
  • Compared to free tannic acid and physical mixtures, CMTA significantly improved human dermal fibroblast viability (approx. 73%) and proliferation (approx. 70%).

Conclusions:

  • The developed chitosan-based microparticles effectively encapsulate tannic acid, improving its properties for wound healing applications.
  • CMTA possess broad-spectrum antimicrobial activity against common wound pathogens.
  • The enhanced biocompatibility and wound healing potential of CMTA make them a promising alternative for managing complex wounds and combating antibiotic resistance.