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Deep Brain Stimulation Electrode Reconstruction: Comparison between Lead-DBS and Surgical Planning System.

Yichen Xu1, Guofan Qin1, Bojing Tan2

  • 1Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Journal of Clinical Medicine
|March 11, 2023
PubMed
Summary

Lead-DBS software shows reasonable accuracy for deep brain stimulation (DBS) electrode reconstruction, despite minor coordinate differences compared to Surgiplan. The software effectively captures the relative distance to the subthalamic nucleus target.

Keywords:
DBS programmingLead-DBScontact coordinatedeep brain stimulationelectrode localizationsurgery planning system

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Computational Neuroscience

Background:

  • Accurate electrode placement is crucial for effective deep brain stimulation (DBS).
  • Postoperative reconstruction of DBS electrodes is essential for assessing lead placement and optimizing stimulation parameters.
  • Current methods include manual reconstruction (Surgiplan) and semi-automated software (Lead-DBS), but Lead-DBS accuracy requires thorough validation.

Purpose of the Study:

  • To compare the accuracy of DBS electrode reconstruction between the Lead-DBS toolbox and the Surgiplan system.
  • To evaluate the performance of Lead-DBS in capturing electrode coordinates and relative positions to the subthalamic nucleus (STN).

Main Methods:

  • Compared Lead-DBS and Surgiplan reconstructions in 26 patients (Parkinson's disease, dystonia) undergoing STN-DBS.
  • Analyzed electrode contact coordinates and relative positions to the STN using postoperative CT and MRI.
  • Mapped optimal stimulation contacts onto Lead-DBS reconstructions to assess STN overlap.

Main Results:

  • Significant differences in X, Y, and Z coordinates were observed between Lead-DBS and Surgiplan using postoperative CT.
  • Y and Z coordinates showed significant differences with both CT and MRI.
  • No significant difference was found in the relative distance between the electrode and the STN.
  • 70% of optimal contacts in Lead-DBS reconstructions were within the STN's dorsolateral region.

Conclusions:

  • Despite coordinate discrepancies of approximately 1 mm, Lead-DBS demonstrates reasonable accuracy for postoperative DBS electrode reconstruction.
  • Lead-DBS effectively maintains the relative spatial relationship between the electrode and the DBS target (STN).
  • The findings support the utility of Lead-DBS for clinical applications in DBS surgery.