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COVID-19 and the Response to Antiplatelet Therapy

Tomáš Bolek1, Matej Samoš1, Jakub Jurica1

  • 1Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 59 Martin, Slovakia.

Journal of Clinical Medicine
|March 11, 2023
PubMed

Insights

Coronavirus disease (COVID-19) increases the risk of blood clots due to hemostasis disorders. This review examines the role of antiplatelet therapy in managing COVID-19 patients and preventing thromboembolism.

Area of Science:

  • Internal Medicine
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 is associated with significant morbidity and mortality.
  • The disease causes hemostasis disorders, including coagulopathy, platelet activation, vascular injury, and fibrinolysis changes.
  • These factors contribute to an increased risk of venous and arterial thromboembolism.

Purpose of the Study:

  • To review current knowledge on the role of antiplatelet therapy in COVID-19 patients.
  • To discuss the challenges in determining the optimal antithrombotic strategy for COVID-19.
  • To explore the mechanisms of platelet activation and coagulation in COVID-19.

Main Methods:

  • Literature review of studies on COVID-19, hemostasis, and thrombosis.
  • Analysis of data on the incidence of venous and arterial thrombosis in COVID-19 patients.
  • Synthesis of information on antiplatelet agents and their potential use in COVID-19.

Main Results:

  • COVID-19 patients exhibit high rates of venous and arterial thrombosis.
  • Arterial thrombosis incidence is approximately 1% in severe/critically ill ICU patients.
  • Multiple pathways contribute to thrombus formation, complicating treatment decisions.

Conclusions:

  • Antiplatelet therapy may play a role in managing COVID-19-associated thrombosis.
  • Further research is needed to establish optimal antithrombotic strategies.
  • Understanding the hemostatic changes in COVID-19 is crucial for patient care.

Keywords:
COVID-19antiplatelet therapyarterial thrombosisaspirin

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