Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

183
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
183
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

167
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
167
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

123
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
123
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

110
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
110
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

160
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
160

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal Cancer Genetics and Hereditary Colorectal Cancer Syndromes for the Practicing General Surgeon.

The Surgical clinics of North America·2026
Same author

Benjamin Allar, MD, MPH, and Evangelos Messaris, MD, PhD.

Clinics in colon and rectal surgery·2026
Same author

Determinants of fecal diversion prior to rectovaginal fistula surgery.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same author

Air Change Setbacks and Surgical Outcomes and Energy Use in Operating Rooms.

JAMA surgery·2026
Same author

Carrie Y. Peterson, MD, MS, FACS, FASCRS.

Clinics in colon and rectal surgery·2026
Same author

Endorobotic submucosal dissection using the da Vinci SP system: a 101-case experience in robotic transanal surgery.

Surgical endoscopy·2026

Related Experiment Video

Updated: Aug 7, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

316

Stage IV Colorectal Cancer Management and Treatment.

Oscar Hernandez Dominguez1, Sumeyye Yilmaz1, Scott R Steele1

  • 1Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Journal of Clinical Medicine
|March 11, 2023
PubMed
Summary

Advances in surgical and systemic therapies improve survival for metastatic colorectal cancer (mCRC). Understanding evolving treatment options and molecular profiling is key for personalized mCRC management and better outcomes.

Keywords:
metastatic colorectal cancerstage IV colon cancerstage IV rectal cancertreatment of stage IV colorectal cancer

More Related Videos

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

5.8K
Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

490

Related Experiment Videos

Last Updated: Aug 7, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

316
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

5.8K
Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

490

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
  • Metastatic colorectal cancer (mCRC) affects up to 50% of CRC patients.
  • Progress in surgical and systemic treatments enhances survival for mCRC.

Purpose of the Study:

  • To summarize current evidence and guidelines for mCRC management.
  • To aid in treatment planning for the diverse mCRC patient population.
  • To highlight evolving therapeutic strategies for mCRC.

Main Methods:

  • Comprehensive literature search of PubMed.
  • Review of current guidelines from major cancer and surgical societies.
  • Screening of references for additional relevant studies.

Main Results:

  • Standard mCRC care involves surgical resection and systemic therapy.
  • Complete resection of metastases (liver, lung, peritoneum) improves survival.
  • Systemic therapy includes chemotherapy, targeted therapy, and immunotherapy, guided by molecular profiling.
  • Management guidelines differ for colon versus rectal metastases.

Conclusions:

  • Advances in surgery, systemic therapy, and molecular profiling prolong survival for mCRC patients.
  • A summary of evidence for mCRC management is provided, noting similarities and differences in guidelines.
  • Multidisciplinary evaluation is essential for optimal mCRC treatment selection.