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Potential Anti-SARS-CoV-2 Molecular Strategies
Caterina Vicidomini1, Giovanni N Roviello1
1Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Area di Ricerca Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy.
Molecules (Basel, Switzerland)
|March 11, 2023
Summary
The main protease (Mpro) of SARS-CoV-2 is a promising target for broad-spectrum antiviral drugs against beta-coronaviruses. Molecular strategies targeting conserved biological mechanisms offer future pandemic preparedness.
Area of Science:
- Virology and Molecular Biology
- Drug Discovery and Development
Background:
- The emergence of SARS-CoV-2 caused a global pandemic, highlighting the need for effective antiviral strategies.
- Previous human betacoronaviruses like SARS-CoV and MERS-CoV necessitated specific therapeutic measures, while others caused common colds.
- While COVID-19 is less severe now, ongoing mutations and potential future pandemics require robust antiviral approaches.
