LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications

Area of Science:

• Analytical Chemistry
• Pharmacology
• Forensic Science

Background:

• The need for rapid, complete screening methods in pharmacotoxicology and forensic cases is critical.
• Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful analytical tool for identification and quantification.
• LC-MS/MS has significantly advanced pharmacological and forensic research.

Purpose of the Study:

• To review the applications of LC-MS/MS in pharmacotoxicological and forensic cases.
• To highlight the role of LC-MS/MS in drug monitoring and illicit drug screening.
• To discuss recent advancements in LC-MS/MS methods for both therapeutic and forensic drug analysis.

Main Methods:

• Review of recent scientific literature (primarily last 3 years) on LC-MS/MS applications.
• Categorization of methods for therapeutic drugs (including TDM and CNS drugs) and illicit drugs.
• Focus on methods applicable to both clinical and forensic fields.

Main Results:

• LC-MS/MS provides comprehensive analysis for accurate analyte identification and quantification.
• The technology supports personalized therapy through effective drug monitoring.
• LC-MS/MS is crucial for screening and researching drugs and illicit substances, aiding law enforcement.

Conclusions:

• LC-MS/MS is an indispensable instrument for modern pharmacotoxicological and forensic analysis.
• Its application facilitates rapid advancements in drug research and personalized medicine.
• The versatility of LC-MS/MS makes it vital for both clinical diagnostics and forensic investigations.