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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Enhanced Drug Delivery System Using Mesenchymal Stem Cells and Membrane-Coated Nanoparticles.

Shubham Joshi1, Sarah Allabun2, Stephen Ojo3

  • 1Department of Computer Engineering, SVKM'S NMIMS Mukesh Patel School of Technology Management and Engineering, Shirpur 425405, Maharashtra, India.

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Summary

Mesenchymal stem cells (MSCs) show promise as drug delivery systems, but standardization is needed. Emerging technologies like nanotechnology enhance MSC-based drug delivery (MSC-DDS) for improved safety and efficacy.

Keywords:
drug delivery systemenhanced particle swarm optimization (E-PSO)mesenchymal stem cell (MSC)nanoparticlespharmacodynamicspharmacokinetics

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Area of Science:

  • Biomedical Engineering
  • Cell Therapy
  • Nanotechnology

Background:

  • Mesenchymal stem cells (MSCs) are emerging as a viable platform for drug delivery systems (DDS).
  • MSC-based DDS (MSC-DDS) show potential in treating various diseases, but face challenges due to intrinsic limitations and lack of standardized assessment methods for safety, efficacy, and biodistribution.

Purpose of the Study:

  • To assess the current status of MSC-based cell therapy, focusing on biodistribution and systemic safety.
  • To explore underlying mechanisms of MSCs concerning tumor initiation and propagation risks.
  • To review methods for MSC biodistribution, pharmacokinetics, and pharmacodynamics, and highlight technologies to enhance MSC-DDS.

Main Methods:

  • Exploration of MSC biodistribution methods, pharmacokinetics, and pharmacodynamics.
  • Review of enhancing technologies: nanotechnology, genome engineering, and biomimetic technology.
  • Application of statistical analyses including ANOVA, Kaplan Meier, and log-rank tests.
  • Development of a shared DDS medication distribution network using enhanced particle swarm optimization (E-PSO).

Main Results:

  • Highlighted the potential of MSCs in gene and drug delivery, including membrane-coated MSC nanoparticles.
  • Identified challenges in clinical translation due to the lack of standardized safety and efficacy assessment methodologies.
  • Demonstrated the utility of E-PSO for optimizing drug distribution networks in DDS.

Conclusions:

  • MSC-based drug delivery systems offer significant therapeutic potential but require standardized methodologies for clinical advancement.
  • Emerging technologies like nanotechnology and genome engineering are crucial for enhancing MSC-DDS effectiveness and safety.
  • Further research into MSC mechanisms and optimized delivery strategies is essential to fully realize their clinical applications.