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Updated: Aug 7, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Updated Progress of the Copper-Catalyzed Borylative Functionalization of Unsaturated Molecules
Bingru Li1, Huayu Liang1, Arumugam Vignesh1,2
1School of Materials Science and Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou 510275, China.
Abstract:
Borylation has become a powerful method to synthesize organoboranes as versatile building blocks in organic synthesis, medicinal chemistry, and materials science. Copper-promoted borylation reactions are extremely attractive due to the low cost and non-toxicity of the copper catalyst, mild reaction conditions, good functional group tolerance, and convenience in chiral induction. In this review, we mainly updated recent advances (from 2020 to 2022) in the synthetic transformations in C=C/C≡C multiple bonds, and C=E multiple bonds mediated by copper boryl systems.
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