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Mass Spectrometry: Complex Analysis

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

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Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

Nanomaterial Characterization in Complex Media-Guidance and Application.

Yves Uwe Hachenberger¹, Daniel Rosenkranz², Charlotte Kromer¹

¹Department of Chemical & Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.

Nanomaterials (Basel, Switzerland)

|March 11, 2023

Summary

This summary is machine-generated.

Measuring nanoparticle dissolution is crucial for assessing environmental and health risks. This study introduces a new ICP-MS method for accurately distinguishing nanoparticles from dissolved ions in complex samples.

Keywords:

characterization dissolution matrix nano spICP-MS

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UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

Published on: October 25, 2021

Area of Science:

Environmental Science
Analytical Chemistry
Toxicology

Background:

Inorganic nanoparticles (NPs) and their dissolved ions pose risks to human health and ecosystems.
Accurate measurement of NP dissolution is challenging due to complex sample matrices.
Understanding NP behavior in biological and environmental fluids is critical for risk assessment.

Purpose of the Study:

To evaluate analytical techniques for characterizing copper oxide (CuO) NPs in complex matrices.
To develop and validate a direct-injection single particle inductively-coupled plasma mass spectrometry (DI spICP-MS) method.
To enable accurate differentiation between NPs and dissolved ions for toxicity studies.

Main Methods:

Investigated CuO NPs dissolution using dynamic light scattering (DLS) and ICP-MS.
Applied DI spICP-MS for size distribution analysis of dissolved particles in undiluted complex matrices.
Developed automated data evaluation for distinguishing NP and ionic events.

Main Results:

DLS and ICP-MS provided time-dependent NP characterization in artificial lung lining fluids and cell culture media.
The DI spICP-MS technique demonstrated high sensitivity for detecting dissolved particles at low concentrations.
Automated data analysis enabled fast and reproducible determination of NPs and ionic backgrounds.

Conclusions:

The DI spICP-MS method offers a sensitive and robust approach for NP characterization in complex matrices.
Accurate differentiation of NPs from dissolved ions is essential for understanding NP toxicity.
This study provides guidance for selecting analytical methods in NP risk assessment.