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Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke-An Update
Salaheldin Abdelraouf Abdelsalam1,2, Kaviyarasi Renu3, Hamad Abu Zahra1
1Department of Biological Sciences, College of Science, King Faisal University, Chennai 31982, Saudi Arabia.
Nutrients
|March 11, 2023
Summary
Polyphenolic compounds like gallic acid and resveratrol show antioxidant effects that may protect against ischemic stroke. These natural products combat oxidative stress, a key factor in stroke-related brain damage.
Area of Science:
- Neuroscience
- Biochemistry
- Pharmacology
Background:
- Stroke is a leading cause of death and disability worldwide.
- Ischemic stroke, caused by disrupted cerebral blood flow, accounts for 80-85% of stroke cases.
- Oxidative stress plays a critical role in the pathophysiology of ischemic stroke, mediating toxicity and inflammation.
Purpose of the Study:
- To review the antioxidant effects of specific polyphenolic compounds.
- To explore their potential protective activity against ischemic stroke.
- To highlight natural products as a potential therapeutic avenue.
Main Methods:
- Literature review of studies on polyphenolic compounds and oxidative stress.
- Focus on gallic acid, resveratrol, quercetin, kaempferol, mangiferin, epigallocatechin, and pinocembrin.
- Analysis of antioxidant mechanisms, including free radical scavenging and enzyme modulation.
Main Results:
- Polyphenolic compounds demonstrate significant free radical scavenging abilities.
- These compounds can enhance the body's natural antioxidant enzyme expressions.
- Evidence suggests protection against reactive oxygen species-mediated cellular injury.
Conclusions:
- Polyphenols possess potent antioxidant properties relevant to stroke prevention.
- Their ability to counteract oxidative stress indicates therapeutic potential for ischemic stroke.
- Natural products offer a promising strategy for mitigating stroke-induced brain damage.
