Related Experiment Video

Updated: Aug 7, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

600

Metabolic Profile of Patients with Long COVID: A Cross-Sectional Study

Daniel Carvalho de Menezes1, Patrícia Danielle Lima de Lima1, Igor Costa de Lima1

  • 1Center for Biological Health Sciences, State University of Pará (UEPA), Belém 66087-670, Brazil.

Nutrients
|March 11, 2023
PubMed

Insights

Long COVID patients often show metabolic imbalances, including high body mass index and abnormal blood markers. These metabolic issues correlate with more severe long COVID symptoms and previous hospitalizations.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Infectious Disease Epidemiology

Background:

  • Post-acute sequelae of coronavirus disease 2019 (Long COVID) present with diverse symptoms.
  • Metabolic parameter imbalances are increasingly recognized in Long COVID patients.
  • Understanding clinical and laboratory markers is crucial for managing Long COVID.

Purpose of the Study:

  • To identify clinical and laboratory markers associated with the disease course in Long COVID patients.
  • To analyze metabolic, glycaemic, and inflammatory profiles in relation to Long COVID severity.
  • To investigate the link between metabolic abnormalities and Long COVID outcomes in the Amazon region.

Main Methods:

  • Cross-sectional analysis of 215 Long COVID patients from a clinical care program.
  • Collection of clinical, sociodemographic, glycaemic, lipid, and inflammatory data.
  • Comparison of marker prevalence between different Long COVID outcome groups.

Main Results:

  • Abnormal metabolic profiles (high BMI, triglycerides, HbA1c, ferritin) were more common in severe Long COVID presentations.
  • Previous hospitalization during acute COVID-19 was associated with worse Long COVID outcomes.
  • Fatigue, dyspnoea, and muscle weakness were the predominant Long COVID symptoms.

Conclusions:

  • Abnormal metabolic profiles are prevalent in patients with worse Long COVID.
  • These findings suggest a link between Long COVID and cardiometabolic health disturbances.
  • Further research into metabolic interventions for Long COVID is warranted.

Keywords:
cardiometabolic risk factorslaboratory markerslong COVID

More Related Videos

Assessment of the Metabolic Profile of Primary Leukemia Cells06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.6K
The MPLEx Protocol for Multi-omic Analyses of Soil Samples10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

11.1K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
402
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
18
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.3K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
416