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High-Content Aloe vera Based Hydrogels: Physicochemical and Pharmaceutical Properties
Mariana Chelu1, Monica Popa1, Emma Adriana Ozon2
1"Ilie Murgulescu" Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania.
Polymers
|March 11, 2023
Summary
New hydrogels incorporating Aloe vera were developed and characterized for their physicochemical and pharmacotechnical properties. The FA-10 formulation, with 10% Aloe vera, showed optimal interactions and is suitable for biomedical applications.
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Hydrogels are versatile biomaterials with applications in drug delivery and tissue engineering.
- Incorporating natural compounds like Aloe vera can enhance hydrogel properties.
- Understanding the structure-property relationships of composite hydrogels is crucial for their development.
Purpose of the Study:
- To synthesize and characterize novel hydrogels using allantoin, xanthan gum, salicylic acid, and varying concentrations of Aloe vera.
- To evaluate the physicochemical and pharmacotechnical properties of these Aloe vera composite hydrogels.
- To determine the optimal Aloe vera concentration for potential biomedical applications.
Main Methods:
- Differential Scanning Calorimetry (DSC) and Thermogravimetric/Derivative Thermogravimetric (TG/DTG) analyses for thermal behavior.
- X-ray Diffraction (XRD), Fourier-Transform Infrared (FTIR), and Raman spectroscopies for chemical structure.
- Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) for morphology.
- Pharmacotechnical evaluations including tensile strength, elongation, moisture content, swelling, and spreadability.
Main Results:
- Hydrogel appearance was homogeneous, with color deepening with increased Aloe vera concentration.
- All formulations exhibited adequate pH, viscosity, spreadability, and consistency.
- SEM and AFM revealed condensed, homogeneous polymeric solids, correlating with decreased XRD peak intensities.
- FTIR, TG/DTG, and DSC analyses indicated interactions between the hydrogel matrix and Aloe vera.
Conclusions:
- The developed Aloe vera composite hydrogels possess favorable physicochemical and pharmacotechnical properties.
- Interactions between the hydrogel matrix and Aloe vera were confirmed through various analytical techniques.
- The FA-10 formulation, containing 10% Aloe vera, demonstrated optimal interactions and is recommended for further biomedical applications.
