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Updated: Aug 7, 2025
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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
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The animal's microbiome and cancer: A translational perspective
Catarina Sofia Aluai-Cunha1,2,3,4, Catarina Alves Pinto1, Isabel Alexandra Duarte Ferreira Lopes Correia3,5
1Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, R. Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal.
Veterinary and Comparative Oncology
|March 11, 2023
Summary
The study explores the connection between the gut microbiome and cancer in humans and companion animals. Findings reveal similarities in cancer types and microbiome composition, offering insights for One Health oncology approaches.
Area of Science:
- Comparative oncology
- Microbiome research
- Translational medicine
Background:
- Cancer incidence is rising globally in humans and animals.
- The commensal microbiota influences physiological and pathological processes.
- Microbiome's role in anti- or pro-tumor effects is increasingly recognized.
Purpose of the Study:
- To review and summarize the relationship between microbiota and cancer in humans and companion animals.
- To compare similarities in neoplasms between species.
- To explore One Health applications for diagnostics and therapeutics.
Main Methods:
- Review of existing literature on microbiota and cancer.
- Analysis of high-throughput DNA sequencing data.
- Comparative analysis of canine, feline, and human gut microbiomes.
Main Results:
- Canine and feline gut microbiome show similarities to human gut microbiome.
- Identified common neoplasms studied in veterinary medicine: lymphoma, colorectal tumors, nasal neoplasia, mast cell tumors.
- Highlighted the translational potential of microbiome research.
Conclusions:
- Integrative microbiome studies can advance understanding of tumorigenesis.
- Microbiome research offers opportunities for novel diagnostic and therapeutic biomarkers.
- One Health approach is crucial for advancing veterinary and human oncology.
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