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Author Spotlight: Enhancing Donor Heart Preservation Through Isolated Rat Heart Perfusion Studies
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Long-distance donor heart procurement using an innovative cold static storage system.

Martin O Schmiady1, Leszek P Bec1, Mohammed Shallah1

  • 1Clinic for Cardiac Surgery, University Heart Center, Zurich, Switzerland.

Perfusion
|March 11, 2023
PubMed
Summary
This summary is machine-generated.

Innovative cold storage solutions enable longer transport distances and times for donor hearts, addressing donor shortages in heart transplantation. This technology expands the potential donor pool for life-saving procedures.

Keywords:
controlled cold storageheart transplantationhypothermic injuryischemic timeorgan transportation

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Area of Science:

  • Cardiology
  • Transplantation Surgery
  • Biomedical Engineering

Background:

  • Global donor shortage significantly limits heart transplantation availability.
  • Expanded donor criteria, including extended transport and ischemia, aim to increase donor pool access.
  • Advancements in cold storage are crucial for utilizing donor hearts with prolonged preservation times.

Purpose of the Study:

  • To report on a long-distance donor heart procurement case.
  • To highlight the use of an innovative cold storage system for extended transport.
  • To demonstrate the feasibility of utilizing donor hearts with unprecedented transport distances and times.

Main Methods:

  • Utilized the SherpaPak™ cold storage system for donor heart transport.
  • Undertook a long-distance donor heart procurement mission.
  • Documented the transport distance and time, establishing a new literature record.

Main Results:

  • Successfully procured and transported a donor heart over the longest reported distance and time.
  • Maintained controlled temperatures throughout the extended transportation period using SherpaPak™.
  • Demonstrated the viability of extended ischemic times for donor heart preservation.

Conclusions:

  • Innovative cold storage systems like SherpaPak™ can overcome geographical limitations in organ procurement.
  • Extended transport distances and prolonged ischemic times are feasible with advanced preservation technology.
  • This approach can significantly expand the donor pool for heart transplantation, addressing critical shortages.