Related Experiment Video
Updated: Feb 6, 2026

Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration
Published on: May 9, 2020
Post-traumatic diffuse brain swelling: isolated or associated with cerebral axonal injury. Clinical course and
F Cordobes1, R D Lobato, J J Rivas
1Department of Neurosurgery, Hospital l de Octubre, Madrid, Spain.
Insights
Computed tomography (CT) findings in children with severe head injuries can predict outcomes. Those with small ventricles and cisterns had better results than those with additional hemorrhages, who faced severe complications and higher mortality.
Area of Science:
- Pediatric Neurology
- Neuroradiology
- Trauma Surgery
Background:
- Severe head injuries in children often lead to diffuse brain swelling, a critical condition.
- Computed tomography (CT) is a key diagnostic tool for evaluating traumatic brain injuries.
Purpose of the Study:
- To investigate the correlation between specific CT findings and clinical outcomes in pediatric severe head injuries.
- To differentiate prognostic indicators based on CT-evaluated intracranial characteristics.
Main Methods:
- Study included 18 children with severe head injuries and diffuse brain swelling.
- Patients were categorized into two groups based on CT scans: Group 1 (small ventricles/cisterns) and Group 2 (Group 1 findings plus intraparenchymal/intraventricular hemorrhage).
Main Results:
- Group 1 (7 patients) showed favorable outcomes with easily controlled intracranial pressure.
- Group 2 (11 patients) presented with more severe clinical conditions, frequent uncontrollable intracranial hypertension, and >50% mortality.
Conclusions:
- CT findings, specifically the presence of intraparenchymal or intraventricular hemorrhage alongside ventricular/cisternal abnormalities, are critical prognostic indicators in pediatric severe head injuries.
- Early identification of these CT markers can aid in predicting patient outcomes and guiding management strategies.
Abstract:
Eighteen children with severe head injuries and diffuse brain swelling were studied. They were separated into two groups based on the computed tomography (CT) findings. Seven patients had small ventricles in the normal location and small or absent cisterns. Eleven had these signs plus small deep-seated intraparenchymal hemorrhagic foci and/or intraventricular hemorrhage. Patients in the first group were in relatively good neurological condition; their intracranial pressure was easily controlled and all had a favourable outcome. On contrast, children in the second group had a more severe clinical presentation, frequently had uncontrollable intracranial hypertension, and more than 50% died.
Related Concept Videos
Acute Kidney Injury III: Clinical Manifestations
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Diffusion
Diffusion
Osmosis and Osmotic Pressure of Solutions
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

