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Space-time trends of community-onset Staphylococcus aureus infections in children: a group-based trajectory modeling

Lilly Cheng Immergluck1, Ruijin Geng1, Chaohua Li2

  • 1Clinical Research Center - Pediatric Clinical & Translational Research Unit, Atlanta, GA; Morehouse School of Medicine, Department of Microbiology/Biochemistry/Immunology, Atlanta, GA.

Annals of Epidemiology
|March 11, 2023
PubMed
Abstract

Insights

Staphylococcus aureus (S. aureus) infection trends from 2002-2016 show distinct spatial patterns. Methicillin-resistant S. aureus (MRSA) disparities were observed, particularly in urban areas, highlighting the need for targeted interventions.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Staphylococcus aureus (S. aureus) is a significant global pathogen.
  • Methicillin-resistant S. aureus (MRSA) is a primary cause of skin and soft tissue infections in the U.S.

Purpose of the Study:

  • To identify and analyze S. aureus infection trends from 2002 to 2016.
  • To assess the spatial distribution of these trends using group-based trajectory modeling.

Main Methods:

  • Retrospective analysis of electronic health records for pediatric S. aureus infections in the southeastern U.S. (2002-2016).
  • Application of group-based trajectory modeling to define low, high, and very high infection trends.
  • Spatial significance assessment at the census tract level, focusing on community-onset infections.

Main Results:

  • Identified three distinct trends (low, high, very high) for both methicillin-susceptible S. aureus (MSSA) and MRSA infections.
  • 29% of census tracts exhibited the best (low infection) trend for both MSSA and MRSA, more prevalent in less populated areas.
  • Significant racial disparities were noted in the worst MRSA infection trends, predominantly in urban settings.

Conclusions:

  • Group-based trajectory modeling effectively revealed spatio-temporal trends in S. aureus infections.
  • The findings provide insights into population characteristics associated with community-onset S. aureus infection trends.
  • Identified disparities underscore the need for geographically targeted public health strategies.
Keywords:
Community onset methicillin-resistant Staphylococcus aureusCommunity onset methicillin-susceptible Staphylococcus aureusGroup-based trajectory modelingHotspot mappin

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