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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Published on: June 15, 2016

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MicroRNAs as master regulators of FOXO transcription factors in cancer management

Madhu Rani1, Rashmi Kumari1, Shashi Prakash Singh2

  • 1Genome Biology Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.

Life Sciences
|March 11, 2023
PubMed

Insights

MicroRNAs regulate FOXO proteins, crucial tumor suppressors. Targeting this microRNA-FOXO axis offers a promising strategy to overcome cancer chemo-resistance and improve treatment outcomes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs are key regulators of gene expression.
  • FOXO transcription factors are vital tumor suppressors involved in critical cellular processes.
  • Dysregulation of FOXOs by microRNAs contributes to cancer development and chemo-resistance.

Purpose of the Study:

  • To discuss the structure and functions of FOXO proteins.
  • To explore the role of microRNAs in regulating FOXOs at the post-transcriptional level.
  • To highlight the potential of the microRNA-FOXO axis as a novel cancer therapy.

Main Methods:

  • Literature review on microRNA and FOXO functions.
  • Analysis of post-transcriptional regulation mechanisms.
  • Discussion of therapeutic implications.

Main Results:

  • FOXO proteins regulate apoptosis, cell cycle, differentiation, and ROS detoxification.
  • MicroRNAs down-regulate FOXOs, promoting tumor initiation and progression.
  • Aberrant microRNA-FOXO interactions are implicated in chemo-resistance.

Conclusions:

  • The microRNA-FOXO axis plays a significant role in carcinogenesis.
  • Targeting microRNAs offers a potential strategy to restore FOXO function.
  • MicroRNA-based therapies may effectively combat cancer chemo-resistance.
Keywords:
CancerCancer therapyChemo-resistanceFOXOForkhead box dependent transcription factorsMicroRNAs

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