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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Correction to: Real-world outcomes of thrombectomy for distal medium vessel occlusions in the Middle East and North Africa region: a multicenter registry analysis.

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MTAS-MENA: adapting the Stroke Access Barrier Index (SABI) to enhance mechanical thrombectomy access in the Middle East and North Africa region.

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Use of Thick Maximum-Intensity Projection Brain Computed Tomography Angiography for Evaluation of Baseline Collateral Status Improves Interrater Agreement.

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Related Experiment Video

Updated: Aug 7, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

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Collateral Circulation in Ischemic Stroke: An Updated Review.

Gino Maguida1, Ashfaq Shuaib1

  • 1Stroke Program, Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Journal of Stroke
|March 12, 2023
PubMed
Summary
This summary is machine-generated.

Collateral circulation is vital for brain tissue perfusion during ischemic stroke, extending treatment times and improving outcomes. Research is advancing understanding and therapeutic targeting of this critical vascular system.

Keywords:
Cerebrovascular circulationCollateral circulationIschemic strokeThrombectomyThrombolytic therapy

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Area of Science:

  • Neurology
  • Vascular Biology
  • Medical Imaging

Background:

  • Collateral circulation is essential for maintaining brain perfusion during ischemic stroke.
  • Understanding this vascular bypass system is crucial for improving patient outcomes.
  • Despite advancements, therapeutic potentiation of collateral circulation remains a challenge.

Purpose of the Study:

  • To provide a structured and updated review of collateral circulation in ischemic stroke.
  • To highlight ongoing research and future clinical applications.
  • To emphasize the role of collateral assessment in acute stroke management.

Main Methods:

  • Review of current literature on collateral circulation in ischemic stroke.
  • Analysis of neuroimaging techniques for collateral assessment.
  • Discussion of therapeutic strategies and future research directions.

Main Results:

  • Collateral circulation significantly impacts stroke severity and recovery.
  • Neuroimaging assessment of collaterals is integral to acute stroke protocols.
  • Advanced understanding aids in patient selection for reperfusion therapies.

Conclusions:

  • Collateral circulation is a key determinant of clinical outcomes in ischemic stroke.
  • Routine assessment improves acute stroke management and prognostication.
  • Further research holds promise for novel therapeutic interventions targeting collaterals.