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Related Experiment Video

Updated: Aug 7, 2025

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

Human microglial models to study host-virus interactions.

Rachel E McMillan¹, Ellen Wang², Aaron F Carlin³

¹Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, United States of America; Department of Pathology and Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States of America.

Experimental Neurology

|March 12, 2023

Summary

This summary is machine-generated.

Microglia play a dual role in neurotropic viral infections, acting as both protectors and facilitators of disease. Understanding human microglial responses is key to developing new therapies for viral infections of the brain.

Keywords:

Herpes simplex virus (HSV)Human immunodeficiency virus 1 (HIV-1)Japanese encephalitis virus (JEV)Microglia Neuroinfectious diseases Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)West Nile virus (WNV)Zika virus (ZIKV)iPSC-derived microglia (iMG)

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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Published on: October 7, 2011

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Last Updated: Aug 7, 2025

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

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A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation

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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Published on: October 7, 2011

Area of Science:

Neuroscience
Immunology
Virology

Background:

Microglia, the central nervous system's immune cells, have a complex role in neurotropic viral infections.
They can be protective or detrimental, acting as viral reservoirs and promoting neuroinflammation.
Modeling human microglia is challenging due to interspecies differences and in vitro culture artifacts.

Conclusions:

Accurate modeling of human microglia is crucial for understanding their role in neurotropic viral infections.
Human stem cell-derived microglia represent a promising avenue for future research.
Further investigation is needed to develop targeted therapeutic interventions for neurotropic viral diseases.