Related Experiment Video
Updated: Aug 7, 2025
06:21
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
1.6K
Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis
Journal of Dental Research
|March 13, 2023
Summary
The combination of diabetes mellitus (DM) and edentulism (tooth loss) significantly worsens cognitive function and accelerates cognitive decline in older adults, particularly those aged 65-74. This highlights a critical link between oral health, metabolic conditions, and brain health.
Area of Science:
- Gerontology and Geriatric Medicine
- Neuroscience and Neurology
- Public Health and Epidemiology
Background:
- Diabetes mellitus (DM) is a known risk factor for dementia.
- Tooth loss (edentulism) is increasingly linked to cognitive impairment and dementia.
- The combined impact of DM and edentulism on cognitive decline remains understudied.
Purpose of the Study:
- To assess the effect of co-occurring DM and edentulism on cognitive decline in older adults.
- To investigate if this effect varies across different age groups (65-74, 75-84, 85+).
Main Methods:
- A 12-year longitudinal cohort study using data from the Health and Retirement Study (2006-2018).
- Included 5,440 adults aged 65-74, 3,300 aged 75-84, and 1,208 aged 85+.
- Linear mixed-effect regression models were used to analyze cognitive decline rates stratified by age.
Main Results:
- Co-occurrence of DM and edentulism was associated with worse cognitive function in adults aged 65-74 and 75-84.
- This combination accelerated cognitive decline rates in the 65-74 age group.
- DM alone accelerated decline in 65-74 year olds; edentulism alone accelerated decline in 65-74 and 75-84 year olds.
Conclusions:
- The co-occurrence of diabetes mellitus and edentulism significantly impairs cognitive function and hastens cognitive decline in older adults, especially those aged 65-74.
- Both diabetes and edentulism as individual factors also contribute to accelerated cognitive decline in specific age groups.
- Findings underscore the importance of managing both metabolic health and oral health for cognitive preservation in aging populations.
Related Concept Videos
01:19Psychoneuroimmunology: Diabetes and Cancer
53
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
53
01:15Diabetes: Symptoms, Diagnosis, and Complications
625
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
625
01:15Teeth
536
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
536
01:22Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
01:30Cognitive Development During Adulthood
179
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
179
01:30Dementia
150
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
150