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Blood pressure variability in Parkinson's Disease patients - Case control study
Mariana Alves1,2,3, Daniel Caldeira4,5, Joaquim J Ferreira2,3,6
1Serviço de Medicina III, Hospital Pulido Valente, CHULN, Lisbon, Portugal.
Clinical Parkinsonism & Related Disorders
|March 13, 2023
Summary
Parkinson's Disease patients may have higher blood pressure variability, indicating a potential increased cardiovascular risk. Further research is needed to confirm this association and its causes.
Area of Science:
- Cardiology
- Neurology
- Hypertension Research
Background:
- Cardiovascular risk in Parkinson's Disease (PD) patients remains unclear.
- Blood pressure variability (BPV) is linked to adverse cardiovascular and mortality outcomes.
- Assessing BPV in PD patients may offer insights into their cardiovascular risk profile.
Purpose of the Study:
- To investigate blood pressure variability (BPV) in Parkinson's Disease (PD) patients.
- To compare BPV between PD patients and matched community controls.
- To evaluate BPV as a potential marker for cardiovascular risk in PD.
Main Methods:
- A cross-sectional, case-control study design was employed.
- Participants underwent clinical evaluation and 24-hour ambulatory blood pressure monitoring.
- Blood pressure variability was quantified using standard deviations of systolic and diastolic blood pressure during 24-hour, daytime, and night-time periods.
Main Results:
- The study included 102 PD patients and 102 controls (mean age 66 years, 59% male).
- Daytime BPV was significantly higher in PD patients (SD SBP: 14.1 vs 12.96 mmHg; SD DBP: 9.39 vs 8.29 mmHg).
- No significant differences in 24-hour or night-time BPV were observed, though PD patients showed a trend towards higher night-time SBP and a greater prevalence of non-dipper/reverse dipper profiles.
Conclusions:
- Parkinson's Disease patients may exhibit elevated blood pressure variability.
- This increased BPV could signify a heightened cardiovascular risk in PD patients.
- Further investigation is required to establish causality and confirm these findings.
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