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LAVAA: a lightweight association viewer across ailments
Eric B Fauman1, Stella Keppo2, Nicola Cerioli2
1Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA.
Motivation:
Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate.
Results:
We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the P-value, effect size, case counts, trait class and fine-mapping posterior probability at a single-nucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user interaction with association results in LAVAA can enrich and enhance the biological interpretation of individual loci.
Availability And Implementation:
LAVAA is available as a stand-alone web service (https://geneviz.aalto.fi/LAVAA/) and will be available in future releases of the finngen.fi website starting with release 10 in late 2023.
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