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Related Concept Videos

Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Related Experiment Video

Updated: Aug 7, 2025

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Sudden unexpected death in epilepsy: A bibliometric overview.

Fang Tong1,2, Jian Lin2,3, Zixuan Zeng1

  • 1School of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Frontiers in Neurology
|March 13, 2023
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Sudden unexpected death in epilepsy (SUDEP) research is growing, focusing on clinical aspects and mechanisms. More studies are needed on SUDEP

Keywords:
English literatureSUDEPautopsy ratebibliometric analysisepilepsyresearch interest

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Area of Science:

  • Neurology
  • Epileptology
  • Medical Research Analysis

Background:

  • Sudden unexpected death in epilepsy (SUDEP) remains poorly understood, with limited autopsy findings.
  • Current research struggles to pinpoint the exact causes of SUDEP, often showing no significant pathological changes.

Purpose of the Study:

  • To analyze the trends and frontiers in SUDEP research.
  • To identify leading research regions and areas of focus in SUDEP studies.

Main Methods:

  • Bibliometric analysis of 1803 SUDEP-related papers.
  • Data sourced from the Web of Science Core Collection (2002-2022).

Main Results:

  • A significant increase in SUDEP publications since 2002.
  • Key research areas include clinical features, prevalence, treatment, and mechanisms.
  • The United States and Europe lead SUDEP research; Asia lags behind.

Conclusions:

  • SUDEP research is expanding, with a growing interest in its underlying mechanisms.
  • Further investigation into SUDEP mechanisms and neuropathology is essential.
  • International collaboration and regional focus may impact research progress.