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Antitumor Therapy Targeting the Tumor Microenvironment.

Yuewen Gao1, Zhengwu Pan2, Hongqi Li2

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The tumor microenvironment is crucial for cancer growth and presents therapeutic targets. This review summarizes pharmacological agents targeting the tumor microenvironment, highlighting existing challenges in anticancer treatment.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Tumor progression heavily relies on the surrounding tumor microenvironment (TME).
  • The TME comprises cells, molecules, and vasculature that support tumor growth, invasion, and metabolism.
  • Components of the TME are recognized as potential therapeutic targets for anticancer strategies.

Purpose of the Study:

  • To review pharmacological agents targeting the tumor microenvironment (TME).
  • To summarize agents that directly or indirectly affect cellular or molecular components within the TME.
  • To discuss current difficulties and challenges in TME-targeted anticancer therapy.

Main Methods:

  • Literature review of pharmacological agents.
  • Analysis of agents targeting cellular and molecular components of the TME.
  • Identification and discussion of challenges in TME-targeted therapies.

Main Results:

  • Numerous pharmacological agents have been developed to target the TME.
  • These agents aim to disrupt tumor growth, invasion, and metabolism by acting on TME components.
  • The review consolidates information on existing TME-targeting drugs.

Conclusions:

  • Targeting the tumor microenvironment (TME) offers promising avenues for cancer treatment.
  • Despite advancements, significant challenges remain in developing effective TME-targeted therapies.
  • Further research is needed to overcome these obstacles and improve patient outcomes.