Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026

Same author

Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.

Magnetic resonance in medicine·2026

Same author

A Message From the Editors to Our Reviewers: 2025.

Neurology. Clinical practice·2026

Same author

ODIN Biobank: a Danish cohort for dementia research- cohort profile.

BMJ open·2026

Same author

Differential Progression of Neuroinflammation in Patients with Isolated Rapid-Eye-Movement Sleep Behavior Disorder.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

Positron emission tomography imaging of the cholinergic system in parkinsonian tremor.

Parkinsonism & related disorders·2026

Search research articles

Related Experiment Video

Updated: Aug 7, 2025

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Capillary function progressively deteriorates in prodromal Alzheimer's disease: A longitudinal MRI perfusion study.

Lasse S Madsen^1,2, Rune B Nielsen², Peter Parbo³

¹Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Denmark.

|March 13, 2023

Summary

Cardiovascular risk factors link to Alzheimer's disease (AD). Prodromal AD patients showed impaired cerebral microvascular blood flow, suggesting capillary dysfunction is an early AD pathological event.

Keywords:

Alzheimer’s disease Capillary dysfunction Magnetic resonance imaging Mild cognitive impairment Perfusion

More Related Videos

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

Published on: April 18, 2025

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

Related Experiment Videos

Last Updated: Aug 7, 2025

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

Published on: April 18, 2025

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

Area of Science:

Neurology
Cardiovascular Science
Neuroimaging

Background:

Cardiovascular risk factors are linked to Alzheimer's disease (AD) development.
Cerebral microvascular dysfunction is increasingly implicated in AD progression.

Purpose of the Study:

To investigate two-year changes in cerebral microvascular blood flow.
To compare patients with prodromal AD (pAD-MCI) to other MCI and control groups.

Main Methods:

Magnetic resonance imaging (MRI) was used to assess cerebral microvascular perfusion.
Longitudinal study over two years with three participant groups.

Main Results:

Prodromal AD patients exhibited widespread microvascular perfusion deterioration.
Capillary dysfunction was specifically observed in the pAD-MCI group.
No significant changes were noted in MCI without AD or control groups.

Conclusions:

Capillary perfusion dysfunction is associated with Alzheimer's disease pathophysiology.
This dysfunction may precede other AD hallmarks like amyloid aggregation and neuroinflammation.
Findings support the capillary dysfunction hypothesis of AD.