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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Aug 7, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

TCR sequencing: applications in immuno-oncology research.

Á F Sanromán¹, K Joshi^2,3, L Au^1,4,5,6

¹Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.

Immuno-Oncology Technology

|March 13, 2023

Summary

T-cell receptor (TCR) interactions drive anti-tumor responses. TCR sequencing reveals tumor-specific T cells, explaining how immunotherapies work through T-cell revival and replacement.

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Area of Science:

Immunology
Oncology
Genomics

Background:

T-cell receptor (TCR) interaction with major histocompatibility complex-antigen complexes is crucial for initiating anti-tumor immune responses.
Understanding the specific T cells that recognize tumor neoantigens is key to developing effective cancer immunotherapies.

Purpose of the Study:

To explore the role of TCR sequencing in characterizing T cells that recognize tumor neoantigens.
To investigate the mechanisms of T-cell clonal revival and replacement in the context of immunotherapy responses.

Main Methods:

TCR sequencing analysis was employed to identify and characterize T-cell populations.
The study focused on analyzing T-cell responses in relation to tumor antigens and immunotherapy.

Main Results:

TCR sequencing enables the detailed characterization of T cells targeting specific tumor neoantigens.
Evidence suggests that T-cell clonal revival and replacement are potential mechanisms driving the efficacy of cancer immunotherapies.

Conclusions:

TCR sequencing is a powerful tool for dissecting anti-tumor T-cell responses.
The dynamics of T-cell populations, including revival and replacement, are critical factors in successful cancer immunotherapy.