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Updated: Aug 7, 2025

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1

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Pain Associated With Monkeypox Virus: A Rapid Review.

Alejandro Hallo-Carrasco¹, Christine L Hunt¹, Christian C Prusinski¹

¹Pain Medicine, Mayo Clinic, Jacksonville, USA.

|March 13, 2023

Summary

Severe pain is a major monkeypox complication. This review summarizes treatments like acetaminophen, ibuprofen, and opioids, highlighting the need for clear pain management guidelines for monkeypox virus (MPXV) patients.

Keywords:

acute pain acute pain management monkeypox complications monkeypox treatment monkeypox virus

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Last Updated: Aug 7, 2025

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1

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Published on: April 8, 2009

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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2

Published on: April 10, 2009

Area of Science:

Infectious Diseases
Pain Management
Public Health

Background:

The 2022 monkeypox virus (MPXV) outbreak raised concerns, with severe pain as a distressing complication.
Limited peer-reviewed literature exists for effective MPXV pain management strategies.
Urgent need for research on pain control in MPXV patients was highlighted by the CDC.

Purpose of the Study:

To conduct a rapid review of existing literature on pain management for monkeypox virus (MPXV).
To summarize proposed analgesic treatments for MPXV-associated pain.
To identify gaps in current knowledge and guide future research.

Main Methods:

A systematic literature search was performed following PRISMA guidelines.
Databases were searched from inception until August 19, 2022, for English-language studies.
Studies with original data on pain in MPXV-positive patients were included; 15 studies comprising 1043 cases were analyzed.

Main Results:

Most MPXV patients were male; severe pain was a common reason for seeking medical care and hospitalization.
Proposed treatments included acetaminophen, ibuprofen, opioids, topical lidocaine, metamizole, and rectal therapies for severe anal pain.
Oral and topical analgesics were common; opioids were used for severe pain management.

Conclusions:

This is the first comprehensive summary of proposed MPXV pain treatments.
Guidelines are needed to direct optimal pain management and reduce patient morbidity.
Adjuvant therapies may be crucial but are underutilized in reported cases.