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Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats
Ratnakar Jadhav1, Yogesh A Kulkarni1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai, India.
Abstract:
Alzheimer's disease is a progressive neurodegenerative condition. It is one of the most common 28 forms of dementia accounting for 60-80% of people suffering from dementia. There are very few medications that are approved for the treatment of Alzheimer's disease. Baicalein, belonging to the flavone subclass of flavonoids, has been reported to have a neuroprotective effect by reducing oxidative stress and neuroinflammation, inhibiting the AChE enzyme, and reducing amyloid protein aggregation and toxicity. Memantine is one of the most important drugs used for treating Alzheimer's disease. The purpose of this work was to study the effect of baicalein with memantine on aluminum chloride-induced neurotoxicity in Wistar rats. Aluminum chloride (100 mg/kg p.o.) was administered for 42 days in male Wistar rats to induce neurotoxicity. Baicalein alone (10 mg/kg) and a combination of baicalein (5 mg/kg and 10 mg/kg) with memantine (20 mg/kg) were administered for 42 days. Treatment of baicalein with memantine showed significant improvement in behavioral parameters. The combination reduced oxidative stress and the formation of β-Amyloid plaques and increased brain-derived neurotrophic factor (BDNF) expression. Based on findings, it can be concluded that treatment with baicalein and memantine may slow the progression of neurodegeneration in rats.
Insights
This study shows that combining baicalein and memantine significantly improved cognitive function in rats with Alzheimer
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Alzheimer's disease is a leading cause of dementia, characterized by neurodegeneration.
- Current treatments for Alzheimer's are limited.
- Baicalein, a flavonoid, exhibits neuroprotective properties.
Purpose of the Study:
- To investigate the combined effects of baicalein and memantine on aluminum chloride-induced neurotoxicity in Wistar rats.
- To evaluate the therapeutic potential of this combination in mitigating Alzheimer's-like pathology.
Main Methods:
- Neurotoxicity was induced in male Wistar rats using aluminum chloride (100 mg/kg p.o.) for 42 days.
- Rats were treated with baicalein alone (10 mg/kg) or in combination with memantine (5 or 10 mg/kg baicalein + 20 mg/kg memantine) for 42 days.
- Behavioral tests, oxidative stress markers, beta-amyloid plaque formation, and brain-derived neurotrophic factor (BDNF) expression were assessed.
Main Results:
- The combination of baicalein and memantine significantly improved behavioral parameters in neurotoxic rats.
- This combination therapy reduced oxidative stress and the formation of beta-amyloid plaques.
- Treatment increased the expression of brain-derived neurotrophic factor (BDNF).
Conclusions:
- Combined treatment with baicalein and memantine demonstrates significant neuroprotective effects.
- This therapeutic strategy may offer a promising approach to slow the progression of neurodegeneration in Alzheimer's disease.
- Further research into this combination therapy is warranted.
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