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The nonlinear relationship between thyroid function parameters and metabolic dysfunction-associated fatty liver

Yingying Hu1,2, Fan Zhou3,4, Fang Lei2,5

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Endocrinology
|March 13, 2023
PubMed
Summary
This summary is machine-generated.

Thyroid function parameters show nonlinear links to metabolic dysfunction-associated fatty liver disease (MAFLD). Thyroid hormones like FT3, FT4, and TSH may be modifiable risk factors for MAFLD prevention and treatment.

Keywords:
metabolic dysfunction-associated fatty liver diseasemultivariable-adjusted logistic regression modelsnonlinear relationshiprestricted cubic spline analysisthyroid function parameters

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Area of Science:

  • Endocrinology
  • Hepatology
  • Metabolic Diseases

Background:

  • The link between thyroid function and metabolic dysfunction-associated fatty liver disease (MAFLD) is debated.
  • Limited data exists on thyroid function and MAFLD in Chinese populations.

Purpose of the Study:

  • To investigate the association between thyroid function parameters and MAFLD in a large Chinese cohort.
  • To explore nonlinear relationships using advanced statistical models.

Main Methods:

  • Retrospective cross-sectional study of 177,540 individuals (2010-2018).
  • Analysis of free triiodothyronine (FT3), free tetra-iodothyronine (FT4), and thyroid-stimulating hormone (TSH).
  • Restricted cubic spline (RCS) and multivariable logistic regression models were employed.

Main Results:

  • Nonlinear associations were observed between FT3, FT4, TSH, and MAFLD risk.
  • Higher FT3 levels showed a decreased MAFLD risk beyond a threshold, while FT4 had a negative association.
  • TSH concentration demonstrated a positive association with MAFLD risk, particularly at lower levels.

Conclusions:

  • Thyroid function parameters exhibit complex, nonlinear relationships with MAFLD.
  • Thyroid function may represent novel, modifiable risk factors for MAFLD management.
  • Findings offer new perspectives for MAFLD prevention and therapeutic strategies.