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Updated: Aug 7, 2025

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
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PAI-1 regulates AT2-mediated re-alveolarization and ion permeability

Gibran Ali1, Mo Zhang1,2, Jianjun Chang1

  • 1Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TX, USA.

Research Square
|March 13, 2023
PubMed
Summary

Elevated plasminogen activator inhibitor-1 (PAI-1) in acute lung injury impairs alveolar epithelial regeneration by reducing self-renewal of alveolar type 2 (AT2) cells, especially CD44+ cells.

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